Young lawyer Ryan Newman is unemployed, feels a sissy failure, had diabetes and his medication contributes to suicidal tendencies. While waiting for a menial job his bossy sister Kristen is arranging at the hospital where she works, Ryan agrees to mind new neighbor Jenna Mueller's beloved dog Wilfred, only the canine talks to him, even appears like a costumed human. Ryan feels better having someone to mind and even with rude criticism mixed into primordial suggestions to get a life. Written by KGF Vissers

Ryan enjoyed winning Wilfred's trust, but is forced to break it to trick him to the vet for dental care. The dog shamelessly milks Ryan's guilt to get away with major mischief on the beach. Wilfred still takes cruel revenge by tricking Ryan into thinking Jenna is probably a transsexual, while in fact her hunky boy-friend Drew is sleeping over. Written by KGF Vissers

Wilfred is determined to provoke gentle Ryan, whom he considers more wimp the man, into becoming as competitive as an alpha dog who brutally rapes vanquished rivals. Ryan declines attacking the motorcycle thug who bullies the Patels, only agrees to smoking stolen weed and prefers avoiding beatings by talking his way out. When Spencer finds Ryan's wallet, which Wilfred left behind while stealing weed, arrives curiously, Ryan convince him they were both victims, but finds himself the pushy lunatic's new best friend. Dog catcher Jesse refuses to be bribed into liberating Wilfred when he notices Ryan befriended his arch enemy Spencer, but Ryan handles even that in the end. Written by KGF Vissers

Ryan feels obligated to repay his sister's help, however inappropriate, and therefore must shortly hand Wilfred into Darryl's daycare. The dog feels neglected and behaves strangely depressed.

Ryan and Wilfred volunteer at a hospice and discover Wilfred may have a remarkable secret talent.

Wilfred persuades Ryan to help him get rid of Jenna's boyfriend.

Wilfred's pursuit of a new love interest forces Ryan to swallow his pride - among other things.

When Wilfred learns that Ryan feels responsible for the death of his beloved childhood dog, he goes to otherworldly lengths to help Ryan learn the truth.

Ryan's resentment of his eccentric mother is exacerbated when Wilfred starts treating her like the mum he never had.

Wilfred uses Ryan's unhealthy habit of isolating as a means to rid himself of a neighborhood pest.

Ryan begins to suspect that his friendship with Wilfred may be self-destructive.

Wilfred urges Ryan to sacrifice his newfound happiness for a greater good.

Ryan ignores Wilfred's advice, creating an existential crisis for both of them.