While pursuing the criminal responsible for her best friend's death, Ghost-Spider is mistakenly accused of the crime by both S.H.I.E.L.D. and the NYPD.

As Gwen Stacy (Ghost-Spider) deals with the loss of her friend, she continues hunting for the culprit while also trying to keep up appearances with her friends and band mates.

Best friends Ms. Marvel and Squirrel Girl join forces to apprehend an alleged super-hero-turned- vigilante: Ghost-Spider.

Finally confronting Ghost-Spider, Squirrel Girl and Ms. Marvel discover that there's more to this villain than meets the eye.

Ghost-Spider finally gets the chance to tell her side of the story when she's captured by Squirrel Girl and Ms. Marvel, yet will it be enough to convince them she's innocent?

Ghost-Spider's run from the law finally ends when she's caught by SHIELD agents Patriot and Quake, but everything changes when her true identity is revealed.