Tim has a massive growth on his back that affects his ability to work and socialize. Daniel has debilitating psoriasis that covers 90% of his body. Gloriana and Yolanda are a mother/daughter duo who have bonded over their bumps.

Traci's confidence has been destroyed after years of bullying from the bumps that have plagued her face for 20 years. Ravon has a unique dangling growth on his leg. David has a large lump that envelops his nose, but a surprise encounter gives him hope.

David is back to see Dr. Lee after she spotted a suspicious growth under his eye. Nicole is depressed because of the bumps all over her neck. Steve has a noticeable lump on his forehead. Allen has a growth on his bicep but is terrified of doctors.

Gerard is lumpy... he has nearly a hundred lumps varying in size that coat his entire body. Gina has bloody lesions all over, and nobody has been able to help her. Eric has a large bump on his head that that he calls his on/off button.

Dermatologist Sandra Lee, aka Dr. Pimple Popper, helps patients with unique skin conditions reclaim a life free of disguise and embarrassment.