Disappeared examines the case of Brittanee Drexel from Rochester, New York, who disappeared near Myrtle Beach, South Carolina, after sneaking away for spring break.

Disappeared examines the case of school teacher and former beauty queen Tara Grinstead who vanished from her home in Ocilla, Georgia.

Disappeared goes to Indiana and looks into the case Niqui McCown who vanished from a laundromat shortly before her wedding.

Disappeared goes to Washington state and looks at the case of Tanya Rider who disappeared one evening on her way home from work. She is discovered days later clinging to life in a wrecked car.

Dissappeared examines the case of John and Elizabeth Calvert who vanished shortly after discovering that a business associate was embezzling money from them.

Dissappeared looks into the case of 22-year-old Bradyn Fuksa whose abandoned car is discovered on the side of a Wyoming highway. He may have been fleeing a felony theft charge.

Disappeared looks at the case of Kristi Cornwell who went for a walk and vanished with a scream while having a telephone conversation with her boyfriend.

Disappeared looks at the case of 30-year old April Pitzer a former federal drug informant who disappeared in the Mojave Desert shortly after deciding to move back home to Arkansas.

Disappeared looks into the case of John Glasgow an Arkansas CFO whose SUV was found abandoned in a state park a day after he left his Little Rock home for work.

Disappeared examines the case of Bobby and Sherilyn Jamison who vanished while shopping for land in Oklahoma with their six-year-old daughter Madyson.

Disappeared examines the case of Tim Carney who disappeared on his way to morning prayer at the Gospel Outreach Church. His family grows worried when his car is discovered at the airport abandoned.

Disappeared looks at the case of Jeramy Burt who vanished after texting his wife about making a fresh start. When the burned out remains of his car are discovered in the Idaho desert, his family begins to doubt the story.

Disappeared looks at the case of 17-year old Kara Kopetsky who disappeared after cutting class at high school. When the body another missing girl is found nearby, police suspect a connection.