Allison, a successful, driven doctor, runs into Amy, a larger than life, eccentric woman who claims to be her guardian angel, and whose mission is to help Allison loosen up and see her life from a new perspective.

Allison asks New Kids On The Block favorite Joey McIntyre to help her patch up a relationship with an old friend as part of a lesson Amy's trying to teach her about facing her fears.

Allison takes Amy to a nightclub to help her stop over-thinking everything and let loose, while Marv, suspicious of his daughter's odd new friend, does a background check on Amy.

When Marv balks at allowing Allison to make some changes to their dermatology practice, Amy creates a temporary position for herself in order to help them work things out.

Amy's plan to get Allison to stop caring about looking stupid backfires when Allison makes a spontaneous decision that leads her to meet her soulmate prematurely.

Amy is required to perform 10 good deeds to earn her angel powers back after losing them by cheating at a game.

Amy must play guardian angel to both Allison and Brad after Allison accidentally kills Brad's angel, a honey bee.

When Allison is struck with dating jitters, Amy suggests she have a fling to work out her nerves.

When Allison reveals how stressful Thanksgiving was after the loss of her mother, Amy suggests a Funsgiving instead, with games and untraditional food.

When Allison begins dating a new guy, Amy tries to finagle their first kiss before the window of opportunity closes to turn things into a lasting relationship.

When Amy doesn't have enough money to pay her rent, Allison helps her find a job.

Allison and Amy try to keep Marv from hearing a conversation about guardian angels that they accidentally recorded on his answering machine.

After Amy survives a bus accident, she becomes determined to break up Allison's friend's wedding in order to put Allison's future on track.